:Scientific background

Scientific background for eve therapy

The scientific background of RevitalVision is based on several studies and breakthrough discoveries in the field of neuro-visual science.


The technology uses special visual stimulation - "Gabor Patch" (1), named after the inventor Dennis Gabor, a Nobel wining prize physicist. Dennis Gabor discovered a unique contrast shape, which perfectly matches the neurons receptive fields in the primary visual cortex, which result the optimal visual stimulation. (2)  


In the famous experiment of Hubel & Wiesel (3), changes in electric activity in a cat cortex were examined, in response to visual stimulation presented to a cat. Hubel & Wiesel discovered that specific neurons in the primary visual cortex, respond only to specific visual stimulations, and that the main parameters impacting neural respond are the precise location of the stimulation, the orientation and the spatial frequency. In 1981 Hubel & Wiesel received Nobel Prize for this discovery, which led to the first understanding of the visual processing mechanism in the brain.


In a later study, done by Uri Polat & Others published in NATURE (4), a direct correlation was demonstrated between the contrast level of a single Gabor Patch and a single neuron respond in the primary visual cortex, up to a certain level. It was also shown, that significant neural activity can be achieved applying "lateral masking technique" using Gabor Patches (when presenting 3 Gabors in specific configurations and parameters). The study proved the existence of neural plasticity in an adult brain, that perceptual learning can be modified, and that vision can improve by perceptual learning technique in adults. The vision improvement reflects in improved contrast sensitivity and visual acuity.


RevitalVision special algorithm identify's cortical neural deficits and uses lateral masking technique to stimulate specific neurons in the primary visual cortex in a repetitive manner, creating a visual perceptual learning process. 


1. Gabor (1946), Theory of Communication. Journal of the Institute of Electrical Engineers, London, 93, 429-457. 
2. Daugman. Two-dimensional spectral analysis of cortical receptive field profiles. Vision Res 1980; 20:847-56. 
3. Hubel & Wiesel (1959). Receptive fields of single neurons in the cat’s striate cortex. J Physiol (Lond) 148:574-591 
4. Polat U., Mizobe, K., Kasamatsu, T., Norcia A.M. (1998). Collinear stimuli regulate visual responses depending on Cell's contrast threshold. Nature, 391, 580-584 


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